Episteme Genomics | Biofoundry Services

Empowering discovery through biofoundry services

From gene synthesis through complex whole synthetic genome construction, and mRNA synthesis, our BioXp biofoundry services provide the speed and accuracy of the BioXp system with Gibson Assembly® technology, the most trusted method for building seamless, high-fidelity DNA. Nanopore long-read sequencing verified plasmids and vectors.

The BioXP 3250 system is a fully automated benchtop platform for synthetic biology workflows that offers a complete suite of synthetic biology applications. The system has been designed to expand upon the success of its predecessor, the BioXP 3200, by giving users more flexibility, more capacity, and more applications. The BioXP 3250 system has multi-fragment capabilities, which allow users to clone up to four fragments at a time in the same vector and longer fragment sizes, which expands the choice of applications. The system automates the ability to evaluate a particular segment of a gene with high fidelity, precision, and accuracy, which is particularly true in the field of drug discovery for biologics such as antibody-based therapeutics. The BioXP 3250 system can be used for various workflows, including gene synthesis, clone generation, plasmid preparation, fragment assembly, oligo synthesis, full-length vector construction, combinatorial library generation, sequencing library preparation, mRNA synthesis, and RapidAMP. The BioXP 3250 system's push-button automation, when combined with excellent quality, makes it an ideal tool for synthetic biology workflows. By using the BioXP 3250 system, researchers can streamline their workflows, reduce waste, and improve the quality of their results. The BioXP 3250 system offers a critical solution to common bottlenecks in vaccine development, directly facilitating the ability to get potentially vital vaccines on the market.

Gene Synthesis: The BioXP 3250 can synthesize genes up to 1.8 kb in length, enabling researchers to generate custom DNA constructs for their experiments quickly. This workflow is particularly useful for synthetic biology, genetic engineering, and gene therapy applications. The BioXP 3250 uses a proprietary technology that enables high accuracy and quality of the synthesized DNA sequences, ensuring optimal functionality in downstream applications.
Clones: The BioXP 3250 enables researchers to generate clones of their DNA constructs quickly. BioXp DNA cloning can make error-corrected, de novo synthetic genes of up to 7 kb in length. These can use either the standard made-to-stock vectors or your specific custom vector.
Full-length Vectors: The BioXP 3250 can be used to generate full-length vectors for use in a variety of applications. This workflow involves synthesizing the full-length DNA sequence of a vector, including the promoter, gene of interest, and other regulatory elements. The BioXP 3250 offers high accuracy and quality of the synthesized vectors, enabling optimal functionality in downstream applications.
Combinatorial Libraries: The BioXP 3250 can generate combinatorial libraries of DNA constructs, which can be used for high-throughput screening and other applications. This workflow involves synthesizing and combining DNA sequences in various combinations and permutations to generate a library of diverse constructs. The BioXP 3250 offers high efficiency and accuracy of the combinatorial synthesis, enabling researchers to generate diverse libraries for their research.
Sequencing Libraries: The BioXP 3250 can generate sequencing libraries for use in a variety of applications, including next-generation sequencing. This workflow involves synthesizing and amplifying DNA fragments of various lengths and purities, which can be used for sequencing applications. The BioXP 3250 offers high efficiency and accuracy of the library synthesis, enabling optimal sequencing results.
mRNA: The BioXP 3250 can be used to generate mRNA for a variety of applications, including gene expression and RNA interference. This workflow involves synthesizing mRNA from a DNA template, which can be used for gene expression or RNA interference applications. The BioXP 3250 offers high accuracy and quality of the synthesized mRNA, enabling optimal functionality in downstream applications.
RapidAmp: The BioXP 3250 can be used for RapidAmp, a technology that enables rapid amplification of DNA fragments. This workflow involves synthesizing and amplifying DNA fragments of interest, which can be used for a variety of applications, including genotyping and gene expression analysis. The BioXP 3250 offers fast and efficient amplification of DNA fragments, with high accuracy and quality of the final product.

Increased Speed and Efficiency: The BioXP 3250 system is designed to automate many aspects of synthetic biology workflows, enabling researchers to save time and resources while increasing their productivity.
High Accuracy and Quality: The BioXP 3250 system offers high accuracy and quality of the synthesized DNA constructs, fragments, and oligos, ensuring optimal functionality in downstream applications.
Customizability: The BioXP 3250 system enables researchers to customize their DNA constructs to meet their specific research needs, enabling greater control over their experiments.
Scalability: The BioXP 3250 system is scalable, enabling researchers to synthesize DNA constructs, fragments, and oligos in larger quantities for high-throughput applications.
Cost-effectiveness: The BioXP 3250 system offers a cost-effective alternative to traditional DNA synthesis methods, enabling researchers to save money while still achieving high-quality results.

Overall, the BioXP 3250 system is a powerful tool for researchers in the field of synthetic biology, offering a wide range of workflows and benefits that can help streamline and optimize their research. By partnering with Episteme Genomics Pvt Ltd, researchers can take advantage of our Biofoundry Services, which utilize the BioXP 3250 system to enable faster, more efficient, and more accurate synthetic biology workflows.